Lub tshuab ntub dej ua tiav lub tshuab ua tiav yog hom khoom siv sib xyaw ua ke, uas tuaj yeem siv rau kev sib xyaw cov tshuaj sib xyaw.Yog li ntawm kev siv thev naus laus zis, lub tshuab ntub dej sib xyaw ua ke muaj ob kauj ruam ntawm kev sib xyaw thiab kev sib tsoo, uas tsis tsuas yog txuag lub sijhawm xwb tab sis kuj sib ntsib qhov yuav tsum tau ntawm GMP, txo qis kuab paug thiab txhim kho kev ua tau zoo. Nws yog txoj hauv kev txuag nyiaj ntau dua sai thiab zoo siab txais tos los ntawm cov neeg siv.
Txawm li cas los xij, piv nrog qhov yuav tsum tau ntawm kev npaj txhim kho, cov txheej txheem ib txwm ntawm ntub cov granulation muaj qhov tsis pom tseeb tsis txaus.Nws tau tshaj tawm tias cov tsoos ntub dej granulation cov ntaub ntawv feem ntau tsuas yog muaj suab thaj hmoov, hmoov txhuv nplej siab, dextrin thiab li on.Sugar hmoov muaj pom tseeb hygroscopicity.Starch hauv cov kua qaub, alkali, lossis hauv lub xeev noo noo thiab cua sov, yuav maj mam hydrolyze thiab poob nthuav tawm; Dextrin tuaj yeem cuam tshuam kev txiav txim siab ntawm qee cov tshuaj, yog li cov tsoos ntub dej granule txheej txheem muaj cov kev txwv pom tseeb.
Ntxiv rau, cov cuab yeej siv tshuaj ib txwm txiav txim siab qhov ntau npaum ntawm kev zam los ntawm kev txiav txim siab ntawm qhov sib npaug thiab sib xws ntawm cov ntawv rho tawm, uas cuam tshuam rau cov qauv tswj kev ua haujlwm zoo ntawm kev npaj.Ua rau cov tshuaj hysteretic thiab excipients, yog hais tias cov npaj tau npaj nrog cov granulation ntub. thev naus laus zis, cov roj ntsha yuav ua kom sib xyaw ua ke, uas ua rau adhesion, sawb ntawm cov ntaub ntawv muag, nplaum mesh thiab lwm yam tshwm sim. Cov lus npaj tau yuav nyuaj heev tab sis muaj cov solubility tsis zoo thiab tsis zoo.
Nrog rau qhov nce siab ntawm cov kev lag luam ntawm kev lag luam ntawm cov txheej txheem tshuaj, ntub tshuab granulation kuj tseem xav tau ua ntej nrog Lub Sijhawm, tsuas yog txuag hluav taws xob ntau, txuag hluav taws xob ntau, ntau cov kev nyab xeeb ib puag ncig granulation txoj kev tuaj yeem siv hauv kev ua lag luam.Qhov kev tshawb nrhiav pom tias kev sib xyaw ntawm cov hluav taws xob zoo thiab zoo li qub ziab, ob kauj ruam ziab kom qhuav, tuaj yeem txo lub sij hawm ziab thiab txhim kho kev ua haujlwm.
Nws paub tias cov granule ua los ntawm ntub kev sib xyaw yog qhov tsis xwm yeem, cov kab hauv qhov loj me me thiab zoo meej hauv cov qauv dua li lwm cov txheej txheem granulation ib txwm muaj.
Ua ntej, agitator duav thiab lub tshuab txiav nrawm.Qhia txog kev lag luam, qhov loj thiab faib ntawm qhov loj me me yog ncaj qha ntsig txog cov nplawm nchuav thiab cov cuab yeej txiav nrawm. Thaum cov cuab yeej txiav nrawm qeeb qeeb, qhov me me loj tuaj, thaum lub sijhawm nrawm dua, qhov loj me me poob qis.Thaum qhov ceev ntawm agitator qeeb, lub particle loj yog me, thaum qhov kev ceev nrawm zuj zus, qhov loj me me loj heev Cov.
Thib ob, qhov kev cuam tshuam ntawm kev sib xyaw, txheej txheem txheej txheem thiab sijhawm yog vim muaj qhov ua tiav ntawm qhov hluav taws xob ntau hauv kev ua haujlwm ntawm lub tshuab, qhov kev sib hloov ntawm qhov cuam tshuam lub lauj kaub cov khoom mus rau hauv qhov chaw rov qab, kom lub hauv qab ntawm cov khoom siv lauj kaub raws phab ntsa thiab txawb lub lauj kaub, qhov no ua qhov txiav ntawm qhov muag ntawm cov ntoo mos mos ua kom sai riam txiav, thiab txiav rau hauv qhov loj me sib txawv, li yob sib ib ntu rau ib lub sijhawm nruab nrab ntawm cov hais lus sib npaug kheej kheej maj mam.Nws tuaj yeem pom tias qhov nrawm thiab lub sijhawm ntawm agitator thiab cutter cuam tshuam qhov loj me me ntawm granulation.
Thib peb, cov nyhuv ntawm cov khoom siv thiab cov concentration.Qhov hauv kev tsim cov ntub dej sib xyaw, cawv ntau ntau los yog phau ntawv dextrin feem ntau yog siv rau granulate.Nws yog cov nquag siv cawv txiv hmab rau kho cov granule, vim cawv tsis noj viscosity, thiab nws muaj xoob nyhuv , nws yog qhov zoo tshaj plaws los siv txoj kev no los npaj cov tshuaj ntau ntawm cov tshuaj suav nrog kev siab viscosity.Yog siv dextrin granulation, vim hais tias dextrin viscosity, polymerization, cov npaj tau npaj rau loj thiab ntxhib, kom qhuav qeeb, tsis muaj viscosity ntawm tshuaj Western nrog cov qauv no yog zoo dua.
Tsis tas li ntawd, txawm hais tias siv cov concentrated extract tom qab dilution raws li cov khoom siv, lossis siv dextrin lossis lwm cov ntaub ntawv nplaum, hauv kev tsim cov khoom me me, cov khoom siv slurry concentration tuaj yeem yog thinner me ntsis, xav tau cov khoom loj dua, cov khoom siv slurry concentration tuaj yeem ua ib me ntsis muaj zog.